Three variable  function can be easily implemented using 8:1 multiplexer. 
connect 3 input lines to select lines of mux and connect 8 inputs of mux
 to logic 0 or 1 according to function output. For example, let us say Function is
                                      F(X,Y,Z) = Σ(0,1,3,6)
then
 X,Y,Z will be connected to select lines of Mux and I0 , I1, I3 and I6 
will be connected to logic 1(VDD) and other will be connected to logic 0
For
 a 4 variable function, there are 16 possible combinations. To implement
 4 variable function using 8:1 MUX, use 3 input as select lines of MUX 
and remaining 4th input and function will determine ith input of mux . 
Let us demonstrate it with an example :
| 
A | 
B | 
C | 
D | 
Decimal
   Equivalent | 
F | 
| 
0 | 
0 | 
0 | 
0 | 
0 | 
0 | 
| 
1 | 
0 | 
0 | 
0 | 
8 | 
0 | 
| 
0 | 
0 | 
0 | 
1 | 
1 | 
1 | 
| 
1 | 
0 | 
0 | 
1 | 
9 | 
1 | 
| 
0 | 
0 | 
1 | 
0 | 
2 | 
0 | 
| 
1 | 
0 | 
1 | 
0 | 
10 | 
1 | 
| 
0 | 
0 | 
1 | 
1 | 
3 | 
0 | 
| 
1 | 
0 | 
1 | 
1 | 
11 | 
1 | 
| 
0 | 
1 | 
0 | 
0 | 
4 | 
0 | 
| 
1 | 
1 | 
0 | 
0 | 
12 | 
1 | 
| 
0 | 
1 | 
0 | 
1 | 
5 | 
1 | 
| 
1 | 
1 | 
0 | 
1 | 
13 | 
0 | 
| 
0 | 
1 | 
1 | 
0 | 
6 | 
0 | 
| 
1 | 
1 | 
1 | 
0 | 
14 | 
0 | 
| 
0 | 
1 | 
1 | 
1 | 
7 | 
1 | 
| 
1 | 
1 | 
1 | 
1 | 
15 | 
0 | 
|  | 
| The 4 variable function represented using 8:1 mux | 
ABar = ~A (inverted A)
for A = 0, F = 1
for A = 1, F = 0
Hence F = ~A (for BCD = 101)
I4, (B = 1, C = 0, D = 0), F = A
I1, (B = 0, C = 0,D = 1), F = 1 (irrespective of status of A)
similarly All other inputs can be inferred in the same way.  Thus we can conclude that to implement n variable function, we need 2^(n-1) to 1 MUX and an inverter. n-1 input lines shall be used as select lines and rest one will be used for input of MUX. 
Also read:
Also read:


